อนุมูลอิสระคืออะไร?

อนุมูลอิสระคืออะไร?

Category : สุขภาพ

เชื่อว่าหลายท่านคงจะเคยได้ยินคำโฆษณาของหลายผลิตภัณฑ์ในปัจจุบันว่า ผลิตภัณฑ์ดังกล่าวสามารถต้านอนุมูลอิสระได้ แต่ทีนี้อนุมูลอิสระเป็นอย่างไร แล้วมีผลต่อร่างกายของเราอย่างไรนั้นสามารถพบคำตอบได้ดังนี้
อนุมูลอิสระ คือโมเลกุลของออกซิเจน ซึ่งมีประจุที่มีความไวในการเข้าไปทำปฏิกิริยากับอะไรก็ตามที่อยู่ใกล้ เช่น โปรตีน โครโมโซม กรดอะมิโน ไขมัน คาร์โบไฮเดรต เป็นต้น ซึ่งปฏิกิริยาดังกล่าวจะส่งผลให้เกิดการทำงานผิดปกติของเซลล์ในร่างกาย ก่อให้เกิดโรคและพยาธิสภาพต่างๆ
       อนุมูลอิสระเกิดได้ทั้งจากภายในและภายนอกร่างกาย ดังนี้
1. อนุมูลอิสระที่เกิดภายในร่างกาย

เกิดจากความผิดปกติในกระบวนการเมตาบอลิซึม ซึ่งกระบวนการเมตาบอลิซึม (Metabolism) คือการเปลี่ยนแปลงซึ่งเกิดขึ้นภายในร่างกายที่ทำหน้าที่เปลี่ยนอาหารให้กลายเป็นพลังงานและเสริมสร้างกล้ามเนื้อให้กับร่างกาย ซึ่งหากมีความผิดปกติย่อมส่งผลเสียให้กับร่างกาย รวมทั้งภาวะผิดปกติต่างๆที่เกิดขึ้น เช่น ภาวะของโรค การรับประทานอาหารบางชนิดที่ก่อให้เกิดพิษในร่างกาย เป็นต้น
2. อนุมูลอิสระที่เกิดภายนอกร่างกาย

เกิดจากการติดเชื้อทั้งจากแบคทีเรียและไวรัส การอักเสบชนิดไม่ทราบสาเหตุ เช่น ข้ออักเสบ รูมาตอยด์ โรคเก๊าต์ เป็นต้น อาจเกิดจากการรับสารกัมมันตรังสีต่างๆ สิ่งแวดล้อมที่เป็นมลพิษ เช่นควันเสีย เขม่ารถยนต์ ควันบุหรี่ ยาฆ่าแมลง รวมทั้งอาหารพวกปิ้ง ย่าง เผา อาหารที่ไหม้เกรียม
โดยธรรมชาติของร่างกายคนเราย่อมมีการเสื่อมสลายของเซลล์และมีการสร้างเซลล์ใหม่มาทดแทนโดยอัตโนมัติ แต่พออายุมากขึ้น กระบวนการเสื่อมสลายยังคงทำงานเหมือนเดิม ในขณะที่กระบวนการสร้างเซลล์ใหม่ทดแทนกลับทำงานได้ไม่ทัน ระบบภูมิคุ้มกันในร่างกายก็เสื่อมสภาพ เป็นเหตุให้ผู้สูงอายุล้มป่วยได้บ่อย และแทนที่ระบบภูมิคุ้มกันที่มีอยู่จะช่วยต่อสู้ศัตรูของร่างกาย กลับแปรมาทำร้ายร่างกายของคนคนนั้นเอง ซึ่งสาเหตุที่ทำให้เกิดการเสื่อมสภาพของเซลล์ รวมทั้งทำให้เกิดความผิดปกติภายในร่างกายไม่ใช่อะไรที่ไหนนอกจากอนุมูลอิสระนี่เอง
อนุมูลอิสระเป็นตัวการสำคัญในการก่อให้เกิดการเปลี่ยนแปลงในร่างกายของเรา เนื่องจากอนุมูลอิสระจะเป็นตัวทำลายเซลล์ ซึ่งจะทำลายเซลล์ได้เร็วและมากขึ้นเมื่ออายุของเรามากขึ้น ทำให้กระบวนการซ่อมแซมส่วนที่สึกหรอทำงานไม่ทัน ความบกพร่องในการทำงานของเซลล์ก็จะเกิดขึ้น และเมื่อเซลล์การทำงานบกพร่องมากขึ้น อวัยวะในร่างกายของเราก็ทำงานบกพร่องและเกิดความผิดปกติในร่างกายได้ อนุมูลอิสระถือว่าเป็นต้นเหตุที่ก่อให้เกิดความชราและความเสื่อมสภาพของร่างกาย นอกจากนี้อนุมูลอิสระยังสร้างปัญหาให้กับร่างกายได้มากมาย ทั้งทำให้ผนังหลอดเลือดแข็งตัว ทำลายเซลล์พันธุกรรมหรือดีเอ็นเอ (DNA) ของเราด้วย หรืออาจทำให้เกิดการกลายพันธุ์ของเซลล์ ทำให้เซลล์ดังกล่าวกลายเป็นเนื้อร้าย ซึ่งเป็นสาเหตุของโรคร้ายต่างๆ ตามมา เช่นโรคมะเร็งต่างๆ โรคหลอดเลือดหัวใจ โรคเบาหวาน โรคต้อกระจก เป็นต้น
ส่วนสิ่งที่สามารถช่วยต้านอนุมูลอิสระให้กับร่างกายเรานั้นหาได้ไม่ยาก นั่นก็คือสารเคมีที่มีฤทธิ์ทางชีวภาพที่มีอยู่ในพืชผักผลไม้ที่เรารับประทาน โดยส่วนใหญ่ผักผลไม้ที่เรารับประทานในชีวิตประจำวันจะมีสีสันแตกต่างกันออกไป แต่สีสันจากธรรมชาตินี้ให้คุณค่ากับร่างกาย โดยการนำสารต้านอนุมูลอิสระเข้าสู่ร่างกายเพื่อไปต่อสู้กับอนุมูลอิสระที่อยู่ภายในร่างกายของเรา และยังช่วยป้องกันอนุมูลอิสระไม่ให้มาทำลายเซลล์ต่างๆในร่างกาย ทำให้ร่างกายของเราแข็งแรง ชะลอความชราและปลอดภัยจากโรคร้ายได้

มารู้จัก “อนุมูลอิสระ” ที่เรียก ๆ กัน มันเป็นอย่างไร?
เดี๋ยวร้อนเดี๋ยวฝนเดี๋ยวหนาว ได้เจอคนไม่สบายบ่อย ๆ ดูแล้วคงต้องระมัดระวังสุขภาพกันมากขึ้นนะคะ หลายคนชอบถามว่า มีวิธีป้องกันหรือดูแลตนเองอย่างไรบ้าง เลยอยากให้รู้จักเรื่องของสารต้านอนุมูลอิสระซึ่งมีประโยชน์ทำให้ร่างกายทำหน้าที่หรือป้องกันตนเองได้ดีขึ้นแล้วทำให้อะไรบางอย่างที่ผิดปกติไปดีขึ้นเร็ว โดยเฉพาะการซ่อมแซมตนเองของร่างกาย
อนุมูลอิสระ คืออะไร?

ในกระบวนการเผาผลาญสารอาหารของร่างกายซึ่งมี ความจำเป็นต้องอาศัยออกซิเจนช่วย แต่จะเกิดออกซิเจนที่มีประจุลบ (O2) ซึ่งก็คืออนุมูลอิสระ (free radicals) สารตัวนี้ยังสามารถไปรวมตัวกับสารบางชนิดในร่างกายเรา แล้วก่อให้เกิดเป็นสารพิษที่ทำลายเนื้อเยื่อ หรืออาจไปเปลี่ยนแปลงข้อมูลทางพันธุกรรมภายในเซลล์ ทำให้เซลล์ที่ปกติแปรสภาพไปเป็นเซลล์มะเร็งในที่สุดอนุมูลอิสระ เป็นอนุภาคไม่คงตัว จึงทำปฏิกิริยากับโมเลกุลที่อยู่ติดกันได้อย่างรวดเร็ว เกิดปฏิกิริยาที่เรียกว่า “ออกซิเดชั่น” (Oxidation) ซึ่งอาจก่อผลกระทบที่อันตรายต่อร่างกายได้
อนุมูลอิสระเกิดขึ้นได้อย่างไร?

นอกจากเกิดจากกระบวนการเผาผลาญสารอาหารในร่างกายแล้ว ยังอาจเกิดจากการติดเชื้อทั้งจากแบคทีเรียและไวรัส การอักเสบชนิดไม่ทราบสาเหตุ เช่น ข้ออักเสบรูมาตอยด์ , จากรังสี, สิ่งแวดล้อมที่เป็นมลพิษ เช่น ควันเสียและเขม่าจากเครื่องยนต์, ควันบุหรี่, ยาฆ่าแมลง, การออกกำลังกายอย่างหักโหม
อนุมูลอิสระทำให้เกิดอะไรกับร่างกายบ้าง?

เมื่ออนุมูลอิสระทำปฏิกิริยากับรหัสพันธุรกรรมดีเอ็นเอในนิวเคลียสของเซลล์ อาจทำให้เซลล์กลายพันธ์และกลายเป็นเซลล์มะเร็ง ถ้าเกิดปฏิกิริยาออกซิเดชั่นกับโคเลสเตอรอลในกระแสเลือด จะกระตุ้นให้เกิดไขมันสะสมในหลอดเลือด นำไปสู่โรคหัวใจและหลอดเลือด ทำให้หลอดเลือดในสมองแตกหรือตีบได้ นอกจากนี้ อนุมูลอิสระยังมีส่วนทำให้เกิดต้อกระจก ภูมิต้านทานต่ำ โรคข้ออักเสบและแก่ก่อนวัย
บทบาทของสารต้านอนุมูลอิสระ

สารต้านอนุมูลอิสระทำลายฤทธิ์ของอนุมูลอิสระ โดยป้องกันการเกิดปฏิกิริยาออกซิเดชั่นในส่วนต่าง ๆ ของร่างกาย นอกจากสารต้านอนุมูลอิสระที่ร่างกายสร้างเองแล้ว ในวิตามิน แร่ธาตุ และพฤกษาเคมี (PhytoChemical) ก็มีสารต้านอนุมูลอิสระอยู่ด้วย และช่วยต้านอนุมูลอิสระได้ดีสีสัน ในผัก ผลไม้ กับสุขภาพ ไฟโตนิวเตรียนท์ (Phytonutrient) หรือไฟโตเคมีคอล (Phytochemical) หรือเรียกว่าพฤษเคมี คือสารเคมีต่าง ๆ ที่มีอยู่ในผัก ผลไม้ เป็นสารที่ทำให้เกิด สี กลิ่น รส ในผัก ผลไม้ มีประโยชน์ต่อร่างกายในการเป็นสารต้านอนุมูลอิสระ ซึ่งมีหลายชนิดและจะมีสีสันที่แตกต่างกันไป

ลองมารู้จักพวกเขาอย่างง่าย ๆ ดูประโยชน์ที่จะได้รับกัน เช่นชนิดสีแดง ช่วยกำจัดอนุมูลอิสระ ช่วยป้องกันมะเร็งชนิดต่าง ๆ ลดความเสี่ยงโรคหัวใจ โรคปอด และโรคระบบทางเดินปัสสาวะ มีไฟโตนิวเตรียนท์ (Phytonutrient): ไลโคพีน (Lycopene) เช่น มะเขือเทศ , แตงโม, เกรฟฟรุทสีชมพู (Pink Grapefruit)ชนิดสีม่วง ช่วยลดการจับตัวกันของลิ่มเลือด ป้องกันโรคหลอดเลือดหัวใจและสมองอุดตัน ช่วยในการมองเห็น ช่วยป้องกันโรคความจำเสื่อม มีไฟโตนิวเตรียนท์ (Phytonutrient): แอนโธไซยานิน (Anthocyanins) เช่น องุ่น, บลูเบอรี่ ,สตอเบอร์รี่, หัวบีท, มะเขือม่วงชนิดสีส้ม ช่วยป้องกันผิวจากการทำลายของอนุมูลอิสระและช่วยซ่อมแซมดีเอ็นเอ (DNA) ช่วยในการมองเห็นตอนกลางคืน มีไฟโตนิวเตรียนท์ (Phytonutient): แอลฟาและเบต้าแคโรทีน เช่น แครอท, มะม่วง, แคนตาลูป, มันเทศชนิดสีเหลืองส้ม ช่วยป้องกันโรคหัวใจ ช่วยเซลล์ในร่างกายในการสื่อประสาท ช่วยกระตุ้นภูมิต้านทาน มีไฟโตนิวเตรียนท์ (Phytonutrient): Beta Cryptothanxin เช่น ส้ม, พีช, มะละกอชนิดสีเหลืองเขียว ช่วยลดความเสี่ยงโรคต้อกระจก ช่วยป้องกันหลอดเลือดหนาตัว เสริมความแข็งแรงของกระดูกและฟัน มีไฟโตนิวตรียนท์ (Phytonutrient): Lutein, Zeaxanthine เช่น ผักขม , ข้าวโพด, อะโวคาโด , แตงฮันนีดิวชนิดสีเขียว ช่วยยับยั้งสารก่อมะเร็ง มีไฟโตนิวเตรียนท์ (Phytonutrient): ซัลโฟราเฟน (Sulforaphane), ไอโซไซยาเนท (Isocyanate), อินโดล (Indoles) เช่น บรอคโคลี, กะหล่ำปลี, ผักกาดหอมฝรั่ง, บรัสเซลส์สเปราท์ชนิดสีเขียวขาว ช่วยป้องกันมะเร็ง มีไฟโตนิวเตรียนท์ (Phytonutrients): Quercetin, Kaempferol, Allicin เช่น กระเทียม, หอม, ซีเรอลี, ลูกแพร์ผักผลไม้หลายชนิดที่มีคุณค่าทางโภชนาการสูงโดยเฉพาะกลุ่มไฟโตนิวเตรียนท์ บางชนิดราคาสูง หาทานได้ไม่ง่ายหรือสะดวกนัก อยากจะทานให้ครบ ๆ คงต้องหาทานกัน เพื่อสุขภาพที่ดีของท่าน

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